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Ro 60-0175 fumarate

Chemical Structure : Ro 60-0175 fumarate

CAS No.: 169675-09-6

Ro 60-0175 fumarate (Ro 600175 fumarate)

Catalog No.: PC-35019Not For Human Use, Lab Use Only.

Ro 60-0175 is a potent, selective 5-HT2C receptor agonist with pKi of 9, 7.5, 5.4, 5.2 and 5.6 for human 5-HT2C, 2A, 1A, 6 and 7 receptors respectively.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Ro 60-0175 is a potent, selective 5-HT2C receptor agonist with pKi of 9, 7.5, 5.4, 5.2 and 5.6 for human 5-HT2C, 2A, 1A, 6 and 7 receptors respectively; induces hypolocomotion in rats at doses greater than 0.5 mg/kg s.c.; (0.3 and 1 mg/kg s.c.) simultaneously reduces both unpunished and punished lever pressing, a profile consistent with sedation, induces sedative-like responses via 5-HT(2C) receptor activation in vivo.

Physicochemical Properties

M.Wt 342.751
Formula C15H16ClFN2O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(S)-1-(6-chloro-5-fluoro-1H-indol-1-yl)propan-2-amine fumarate

References

1. Damjanoska KJ, et al. J Pharmacol Exp Ther. 2003 Mar;304(3):1209-16.

2. Vickers SP, et al. Br J Pharmacol. 2000 Jul;130(6):1305-14.

3. Kennett G, et al. Eur J Pharmacol. 2000 Jan 10;387(2):197-204.

4. Jenck F, et al. Eur Neuropsychopharmacol. 1998 Aug;8(3):161-8.

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