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Chemical Structure : Robotnikinin
Catalog No.: PC-62182Not For Human Use, Lab Use Only.
Robotnikinin is asmall molecule that binds the extracellular Sonic Hedgehog (Shh) protein (Kd=3.1 uM) and blocks Shh-signaling in cell lines, human primary keratinocytes and synthetic model of human skin.
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Robotnikinin is asmall molecule that binds the extracellular Sonic Hedgehog (Shh) protein (Kd=3.1 uM) and blocks Shh-signaling in cell lines, human primary keratinocytes and synthetic model of human skin; displays significant repression of Shh-induced Gli1/Gli2, and interferes with the ability of the ShhN protein complex to relay its signal efficiently to Ptc1.
| M.Wt | 454.951 | |
| Formula | C25H27ClN2O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Stanton BZ, et al. Nat Chem Biol. 2009 Mar;5(3):154-6.
2. Hassounah NB, et al. Clin Cancer Res. 2012 May 1;18(9):2429-35.
3. Peng LF, et al. Bioorg Med Chem Lett. 2009 Nov 15;19(22):6319-25.
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