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Chemical Structure : Rofecoxib
Catalog No.: PC-45194Not For Human Use, Lab Use Only.
A potent, selective and orally active COX-2 inhibitor with IC50 of 26 nM for inhibition of the COX-2-dependent production of PGE2 in human osteosarcoma cells.
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A potent, selective and orally active COX-2 inhibitor with IC50 of 26 nM for inhibition of the COX-2-dependent production of PGE2 in human osteosarcoma cells; displays 1,000-fold selectivity over COX-1 activity; selectively inhibits LPS-induced, COX-2-derived PGE(2) synthesis after blood coagulation (IC50=0.53 uM); exhibits anti-inflammation activity in osteoarthritis and rheumatoid arthritis rodent models.
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| M.Wt | 314.3557 | |
| Formula | C17H14O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Chan CC, et al. J Pharmacol Exp Ther. 1999 Aug;290(2):551-60.
2. Ehrich EW, et al. Clin Pharmacol Ther. 1999 Mar;65(3):336-47.
3. Prasit P, et al. Bioorg Med Chem Lett. 1999 Jul 5;9(13):1773-8.
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