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Chemical Structure : Rostafuroxin
CAS No.: 156722-18-8
Catalog No.: PC-42946Not For Human Use, Lab Use Only.
Rostafuroxin (PST2238) is potent, selective, orally active Na-K-ATPase inhibitor, displaces 3H ouabain from dog kidney Na+,K+-ATPase with IC50 of 1.5 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 50 mg | $428 | In stock | |
| 100 mg | $728 | In stock | |
| 500 mg | Get quote |
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Rostafuroxin (PST2238) is potent, selective, orally active Na-K-ATPase inhibitor, displaces 3H ouabain from dog kidney Na+,K+-ATPase with IC50 of 1.5 nM; displays excellent selectivity over a panel of general and hormonal receptors, with exception of thromboxane A2 receptor (61% inhibition at 1 uM); abolishes ouabain-dependent increase in the Na-K pump rate in cultured renal cells, abolishes the increase in blood pressure and renal Na-K ATPase activity caused by ouabain in rats model of hypertension.
Hypertension
Phase 2 Clinical
| M.Wt | 374.5137 | |
| Formula | C23H34O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
24-Norchola-20,22-diene-3,14,17-triol, 21,23-epoxy-, (3β,5β,14β)- |
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1. Quadri L, et al. J Med Chem. 1997 May 23;40(11):1561-4.
2. Ferrari P, et al. J Pharmacol Exp Ther. 1998 Apr;285(1):83-94.
3. Goto A, et al. Hypertension. 1997 Sep;30(3 Pt 2):753-8.
4. Ferrari P, et al. J Pharmacol Exp Ther. 1999 Mar;288(3):1074-83.
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