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Chemical Structure : Ruboxistaurin hydrochloride
CAS No.: 169939-93-9
Catalog No.: PC-42441Not For Human Use, Lab Use Only.
Ruboxistaurin hydrochloride (LY333531) is a potent, selective, ATP-competitive, orally available PKC beta (PKCβ) inhibitor with IC50 of 4.7 and 5.9 nM for PKCβ I and PKCβ II, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 2 mg | $128 | In stock | |
| 5 mg | $198 | In stock | |
| 10 mg | $328 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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Ruboxistaurin hydrochloride (LY333531) is a potent, selective, ATP-competitive, orally available PKC beta (PKCβ) inhibitor with IC50 of 4.7 and 5.9 nM for PKCβ I and PKCβ II, respectively.
Ruboxistaurin hydrochloride (LY333531) displays >60-fold selectivity over PKCα, and other ATP dependent kinases (PKA, Calcium calmodulin, Caesin kinase and Src).
Ruboxistaurin hydrochloride (LY333531) ameliorates the glomerular filtration rate, albumin excretion rate, and retinal circulation in diabetic rats.
| M.Wt | 505.0079 | |
| Formula | C28H29ClN4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 6.8 mg/mL (Need ultrasonic and warming) |
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| Chemical Name/SMILES |
9H,18H-5,21:12,17-Dimethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20(19H)-dione, 9-[(dimethylamino)methyl]-6,7,10,11-tetrahydro-, monohydrochloride, (9S)- (9CI) |
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1. Jirousek MR, et al. J Med Chem. 1996 Jul 5;39(14):2664-71.
2. Ishii H, et al. Science. 1996 May 3;272(5262):728-31.
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