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Chemical Structure : Ruxolitinib S enantiomer
CAS No.: 941685-37-6
Catalog No.: PC-45873Not For Human Use, Lab Use Only.
The chirality of Ruxolitinib (INCB-018424), which is a potent, selective, orally active JAK1/JAK2 inhibitor with IC50 of 3.3/2.8 nM, respectively..
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The chirality of Ruxolitinib (INCB-018424), which is a potent, selective, orally active JAK1/JAK2 inhibitor with IC50 of 3.3/2.8 nM, respectively.
| M.Wt | 306.365 | |
| Formula | C17H18N6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1H-Pyrazole-1-propanenitrile, β-cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-, (βS)- |
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1. Quintás-Cardama A, et al. Blood. 2010 Apr 15;115(15):3109-17.
2. Fridman JS, et al. J Immunol. 2010 May 1;184(9):5298-307.
3. Verstovsek S, et al. N Engl J Med. 2010 Sep 16;363(12):1117-27.
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