Ruzasvir |Cas: 1613081-64-3 Buy Ruzasvir from ProbeChem, Global Biochemicals Supplier

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Chemical Structure : Ruzasvir

Ruzasvir (MK-8408;MK 8408;MK8408)

Catalog No.: PC-60309Not For Human Use, Lab Use Only.

Ruzasvir (MK-8408) is a potent, pan-genotype HCV NS5A inhibitor with replicon EC90 of 0.003, 0.016, 0.067, 0.036, 0.007, and 0.007 nM for GT1a, GT1a L31V, GT1a Y93H, GT2b, GT3a, and Gt4a, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Ruzasvir (MK-8408) is a potent, pan-genotype HCV NS5A inhibitor with replicon EC90 of 0.003, 0.016, 0.067, 0.036, 0.007, and 0.007 nM for GT1a, GT1a L31V, GT1a Y93H, GT2b, GT3a, and Gt4a, respectively.

Ruzasvir (MK-8408) inhibits HCV RNA replication with EC50s of 1 to 4 pM in Huh7 or Huh7.5 cells bearing replicons for HCV genotype 1 (GT1) to GT7.

Ruzasvir (MK-8408) is an HCV NS5A inhibitor with pan-genotypic profile.

Physicochemical Properties

M.Wt	947.09
Formula	C49H55FN10O7S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	Dimethyl N,N'-([(6S)-6-(2-cyclopropyl-1,3-thiazol-5-yl)-1-fluoro-6H-indolo[1,2-c][1,3]benzoxazine-3,10-diyl]bis{(1H-imidazole-4,2-diyl)[(2S)-pyrrolidine-2,1- diyl][(2S)-3-methyl-1-oxobutane-1,2-diyl]})dicarbamate

References

1. Tong L, et al. J Med Chem. 2017 Jan 12;60(1):290-306.

2. Wyles D, et al. Hepatology. 2017 Dec;66(6):1794-1804.

3. Lawitz E, et al. Lancet Gastroenterol Hepatol. 2017 Nov;2(11):814-823.

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Ruzasvir (MK-8408;MK 8408;MK8408)

Biological Activity

Physicochemical Properties

References

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