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S-023-0996

Chemical Structure : S-023-0996

CAS No.:

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S-023-0996

Catalog No.: PC-27851Not For Human Use, Lab Use Only.

S-023-0996 is a potent, tumor cell selective, dual inhibitor of EZH2 and EGFR with IC50 of 2.41 nM and 42.18 nM respectively, inhibits tumor cell proliferation, migration and invasion in vitro with superior efficacy and safety than individual drug combinations.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

S-023-0996 is a potent, tumor cell selective, dual inhibitor of EZH2 and EGFR with IC50 of 2.41 nM and 42.18 nM respectively, inhibits tumor cell proliferation, migration and invasion in vitro with superior efficacy and safety than individual drug combinations.

Physicochemical Properties

M.Wt 857.07
Formula C49H60N8O6
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-5-((4-(2-(2-((4-((3-ethynylphenyl)amino)-7-methoxyquinazolin-6-yl)oxy)ethoxy)ethyl)piperazin-1-yl)methyl)-2-methylbenzamide

References

1. Satrusal SR, et al. Mol Ther. 2026 Aug 25:S1525-0016(26)00715-X.

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