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Chemical Structure : S-17092
Catalog No.: PC-70065Not For Human Use, Lab Use Only.
A highly potent, specific and cell permeant inhibitor of human proline endopeptidase (PE) with Ki of 1 nM.
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A highly potent, specific and cell permeant inhibitor of human proline endopeptidase (PE) with Ki of 1 nM; shows no activity against a series of other peptidases including aminopeptidases B and M, dipeptidylaminopeptidase IV, endopeptidases, calpains and angiotensin-converting enzyme; significantly increases in SP- and alpha-MSH-like immunoreactivity in the frontal cortex and hypothalamus in rats (30mg/kg); shows cognition-enhancing properties in chronic low dose MPTP-treated monkeys.
| M.Wt | 384.53 | |
| Formula | C22H28N2O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Barelli H, et al. Biochem Biophys Res Commun. 1999 Apr 21;257(3):657-61.
2. Bellemère G, et al. J Neurochem. 2003 Mar;84(5):919-29.
3. Schneider JS, et al. Neuropsychopharmacology. 2002 Feb;26(2):176-82.
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