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Chemical Structure : S-Trityl-L-cysteine
Catalog No.: PC-62340Not For Human Use, Lab Use Only.
S-Trityl-L-cysteine (NSC 83265) is a potent, cell-permeable, selective inhibitor of mitotic kinesin Eg5, inhibits basal ATPase activity (IC50=1 mM) and microtubule-activated ATPase activity of Eg5 (IC50=140 nM).
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S-Trityl-L-cysteine (NSC 83265) is a potent, cell-permeable, selective inhibitor of mitotic kinesin Eg5, inhibits basal ATPase activity (IC50=1 mM) and microtubule-activated ATPase activity of Eg5 (IC50=140 nM); induces mitotic arrest in HeLa cells with an IC50 of 700 nM, and displays antitumor activity.
| M.Wt | 363.47 | |
| Formula | C22H21NO2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Brier S, et al. Biochemistry. 2004 Oct 19;43(41):13072-82.
2. DeBonis S, et al. Mol Cancer Ther. 2004 Sep;3(9):1079-90.
3. Zhao J, et al. Am J Cancer Res. 2014 Jan 15;4(1):42-52.
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