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Chemical Structure : S202
Catalog No.: PC-38767Not For Human Use, Lab Use Only.
S202 is a potent, selective and brain-penetrant small molecule inhibitor of ceramide galactosyltransferase (CGT) with IC50 of 15 nM in the cell-lysate assays and 3.6 nM in intact-cell assays.
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S202 is a potent, selective and brain-penetrant small molecule inhibitor of ceramide galactosyltransferase (CGT) with IC50 of 15 nM in the cell-lysate assays and 3.6 nM in intact-cell assays.
S202 exhibits minimal to no activity toward other enzymes that act on related glycosphingolipids.
S202 preferentially reduces non-hydroxy-GalCer synthesis in vivo.
S202 (0-1.5 mg/kg) extends survival and reduces psychosine levels in a krabbe disease (KD) mouse model, causes a dose-dependent reduction in non-hydroxy-GalCer without reducing 2-hydroxy-GalCer in the brain.
S202 (0.15 mg/kg, i.p. three times per week) improves histological and immunological markers in Twitcher mice.
S202 treatment reduces non-hydroxy-sulfatides and lysosulfatide in an MLD mouse model.
| M.Wt | 586.203 | |
| Formula | C23H17Br2F3N2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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