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Chemical Structure : S29434
CAS No.: 874484-20-5
Catalog No.: PC-35919Not For Human Use, Lab Use Only.
S29434 (S 29434) is a highly potent, selective, cell-active inhibitor of Quinone reductase 2 (QR2) with IC50 of 5-16 nM, shows good selectivity for QR2 over QR1.
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S29434 (S 29434) is a highly potent, selective, cell-active inhibitor of Quinone reductase 2 (QR2) with IC50 of 5-16 nM, shows good selectivity for QR2 over QR1.
S29434 inhibits QR2-mediated ROS production within the 100 nM range in various cell types, including hepatoma HepG2 cells, the astroglial cell line U373 and primary dopaminergic neurons.
S29434 (S 29434) is fairly stable in vivo.
| M.Wt | 374.4 | |
| Formula | C21H18N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-(2-(2-methoxy-6H-dipyrido[2,3-a:3',2'-e]pyrrolizin-11-yl)ethyl)furan-2-carboxamide |
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1. Boutin JA, et al. Mol Pharmacol. 2018 Dec 19. pii: mol.118.114231. doi: 10.1124/mol.118.114231.
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