S3226

Chemical Structure : S3226

Catalog No.: PC-26525Not For Human Use, Lab Use Only.

S3226 is a potent, selective Na+/H+ exchanger subtype 3 (NHE3, SLC9A3) inhibitor with IC50 of 0.02 uM (hNHE3), shows >100-fold selectivity over hNHE1 and rbNHE2.

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Biological Activity

S3226 is a potent, selective Na+/H+ exchanger subtype 3 (NHE3, SLC9A3) inhibitor with IC50 of 0.02 uM (hNHE3), shows >100-fold selectivity over hNHE1 and rbNHE2.

Physicochemical Properties

M.Wt	415.32
Formula	C17H24Cl2N6O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2E,2'E)-3,3'-(4-methyl-1,2-phenylene)bis(N-carbamimidoyl-2-methylacrylamide) dihydrochloride

References

1. Schwark JR, et al. Pflugers Arch. 1998 Oct;436(5):797-800.

2. Wiemann M, et al. Pflugers Arch. 1999 Aug;438(3):255-62.

3. Hropot M, et al. Kidney Int. 2001 Dec;60(6):2283-9.

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S3226

Biological Activity

Physicochemical Properties

References

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