S3D5

Chemical Structure : S3D5

Catalog No.: PC-25247Not For Human Use, Lab Use Only.

S3D5 is a potent and selective, BP-1-102-based PROTAC degrader for STAT3 with DC50 of 110 nM in HepG2 cells.

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Biological Activity

S3D5 is a potent and selective, BP-1-102-based PROTAC degrader for STAT3 with DC50 of 110 nM in HepG2 cells.
S3D5 can effectively degrade the STAT3 protein even at low concentrations, but has little effect at any concentration on STAT1, STAT2, STAT4, STAT5 and STAT6 proteins.
S3D5 inhibits the growth of HepG2 cells in a dose-dependent manner.
S3D5 inhibits the invasion and migration of HepG2 cells.
S3D5 positively regulates the p53 signaling pathway and its related effects on the cell growth inhibition.

Physicochemical Properties

M.Wt	956.89
Formula	C41H45F5N6O13S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(17-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12,15-pentaoxaheptadecyl)-4-(2-((2,3,4,5,6-pentafluoro-N-methylphenyl)sulfonamido)acetamido)benzamide

References

1. Wang K, et al. RSC Med Chem. 2025 Jul 31.

S3D5

Biological Activity

Physicochemical Properties

References

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