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Chemical Structure : SACLAC
Catalog No.: PC-72408Not For Human Use, Lab Use Only.
SACLAC is an α-chloroamide ceramide analog that binds irreversibly to acid ceramidase (ASAH1), significantly reduces the viability of AML cells (EC50=3 uM) across 30 human AML cell lines.
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SACLAC is an α-chloroamide ceramide analog that binds irreversibly to acid ceramidase (ASAH1), significantly reduces the viability of AML cells (EC50=3 uM) across 30 human AML cell lines.
SACLAC induces apoptosis and loss of mitochondrial membrane potential, reduces cell viability and colony formation, reduces expression of SF3B1 and increases pro-apoptotic Mcl-1S.
SACLAC (5 mg/kg SACLAC in 45% w/v 2-hydroxypropyl-β-cyclodextrin in PBS) reduces leukemic burden in NSG mouse models of AML.
| M.Wt | 377.994 | |
| Formula | C20H40ClNO3 | |
| Appearance | Solid | |
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1. Jennifer M Pearson, et al. Mol Cancer Res. 2020 Mar;18(3):352-363.
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