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Chemical Structure : SAFit2
CAS No.: 1643125-33-0
Catalog No.: PC-72575Not For Human Use, Lab Use Only.
SAFit2 is a potent and highly selective inhibitor of FKBP51 (K506-binding protein 51) with IC50 of 6 nM, >10,000-fold selectivity over FKBP52.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $258 | In stock | |
| 10 mg | $428 | In stock | |
| 25 mg | $728 | In stock | |
| 100 mg | Get quote | ||
| 200 mg | Get quote | ||
| 1 g | Get quote |
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SAFit2 is a potent and highly selective inhibitor of FKBP51 (K506-binding protein 51) with IC50 of 6 nM, >10,000-fold selectivity over FKBP52.
SAFit2 enhances regulation of stress hormone secretion and active stress-coping behavior in mice.
SAFit2 reduced anxiety-related behavior in the basolateral amygdala (BLA) microinjected mice.
SAFit2 recapitulates the effects of FKBP51 deletion on both body weight regulation and glucose tolerance.
| M.Wt | 803.006 | |
| Formula | C46H62N2O10 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(S)-((R)-3-(3,4-Dimethoxyphenyl)-1-(3-(2-morpholinoethoxy)phenyl)propyl) 1-((S)-2-cyclohexyl-2-(3,4,5-trimethoxyphenyl)acetyl)piperidine-2-carboxylate |
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1. Balsevich G, et al. Nat Commun. 2017 Nov 23;8(1):1725.
2. Gaali S, et al. Nat Chem Biol. 2015 Jan;11(1):33-7.
3. Hartmann J, et al. J Neurosci. 2015 Jun 17;35(24):9007-16.
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