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Chemical Structure : SAN9812
CAS No.:
Catalog No.: PC-35233Not For Human Use, Lab Use Only.
SAN9812 (Carnostatine) is a potent, highly selective, competitive inhibitor of Carnosinase 1 (CN1) activity with Ki of 11 nM.
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SAN9812 (Carnostatine) is a potent, highly selective, competitive inhibitor of Carnosinase 1 (CN1) activity with Ki of 11 nM; displays no activity against a standard panel of 33 different receptors, channels, transporters and enzymes; inhibits human recombinant CN1 at a carnosine concentration of 200 µM with IC50 of 18 nM, also demonstrates inhibitory activity on human CN1 in serum from TG mice-expressing human CN1 and serum from healthy human volunteers with IC50 of 650 and 340 nM, respectively; increases carnosine levels in plasma and kidney in mice.
| M.Wt | 256.262 | |
| Formula | C10H16N4O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
((S)-4-amino-2-hydroxybutanoyl)-L-histidine |
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1. Qiu J, et al. Amino Acids. 2018 Jun 20. doi: 10.1007/s00726-018-2601-z.
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