Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : SANT-1
CAS No.: 304909-07-7
Catalog No.: PC-62171Not For Human Use, Lab Use Only.
SANT-1 is a potent, cell-permeable Smoothened inhibitor (Kd=1.2 nM) that inhibits Sonic hedgehog (Shh) signaling.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $118 | In stock | |
| 25 mg | $188 | In stock | |
| 50 mg | $288 | In stock | |
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
SANT-1 is a potent, cell-permeable Smoothened inhibitor (Kd=1.2 nM) that inhibits Sonic hedgehog (Shh) signaling.
SANT-1 inhibits smoothened agonist effects with an IC50 of 20 nM in Shh-LIGHT2 cells.
SANT-1 significantly reduces Gli1 gene expression, and reduces proliferation of glioma stem-like cells.
| M.Wt | 373.504 | |
| Formula | C23H27N5 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
N-[(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methylene]-4-(phenylmethyl)-1-piperazinamine |
|
1. Chen JK, et al. Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14071-6.
2. Cohen JR, et al. BMC Cancer. 2010 Dec 9;10:676.
3. Dixit D, et al. Cancer Lett. 2013 Aug 19;336(2):347-58.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
