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Chemical Structure : SAR-20347
CAS No.: 1450881-55-6
Catalog No.: PC-35842Not For Human Use, Lab Use Only.
SAR-20347 (SAR20347) is a potent, selective inhibitor of JAK1 and Tyk2 with IC50 of 59 and 13 nM in TR-FRET assays, shows selectivity against JAK2 and JAK3 (IC50>800 nM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $328 | In stock | |
| 100 mg | $898 | In stock | |
| 250 mg | Get quote | ||
| 1 g | Get quote |
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SAR-20347 (SAR20347) is a potent, selective inhibitor of JAK1 and Tyk2 with IC50 of 59 and 13 nM in TR-FRET assays, shows selectivity against JAK2 and JAK3 (IC50>800 nM); potently inhibits IL-12-mediated STAT4 phosphorylation with IC50 of 126 nM, inhibits JAK1-mediated IL-6 pSTAT3 signaling with IC50 of 345 nM in TF-1 and 407 nM in CD4+ cells, poorly inhibits JAK2 mediated STAT5 phosphorylation with IC50 of >1 uM; ameliorates imiquimod-induced psoriasis-like dermatitis in vivo.
| M.Wt | 444.847 | |
| Formula | C21H18ClFN4O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-(2-chloro-6-fluorophenyl)-5-((4-(morpholine-4-carbonyl)phenyl)amino)oxazole-4-carboxamide |
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1. Works MG, et al. J Immunol. 2014 Oct 1;193(7):3278-87.
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