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Chemical Structure : SAR439883
Catalog No.: PC-72066Not For Human Use, Lab Use Only.
SAR439883 (SAR 439883) is a novel potent, selective, orally active PKR inhibitor with IC50 of 0.68/0.69 uM against hPKR/mPKR, respectively.
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SAR439883 (SAR 439883) is a novel potent, selective, orally active PKR inhibitor with IC50 of 0.68/0.69 uM against hPKR/mPKR, respectively.
SAR439883 dose-dependently ameliorated the AβO-induced cognitive impairment in both Y-maze and Morris Water Maze, prevented loss of synaptic proteins, and reduced levels of the proinflammatory cytokine interleukin-1β In both mouse models.
SAR439883 rescued memory deficits and prevented neurodegeneration in animal models of AD-like pathology, suggesting that inhibition of PKR is a potential therapeutic approach for AD.
| M.Wt | 384.852 | |
| Formula | C19H23ClF2N2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Matilde Lopez-Grancha, et al. J Pharmacol Exp Ther. 2021 Sep;378(3):262-275.
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