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Chemical Structure : SARM1 inhibitor NB-3
Catalog No.: PC-49319Not For Human Use, Lab Use Only.
SARM1 inhibitor NB-3 is a small molecule inhibitor of the nicotinamide adenine dinucleotide (NAD) hydrolase SARM1, targets the NAD-dependent active-site by intercepting NAD hydrolysis and undergoing covalent conjugation with the reaction product adenosine diphosphate ribose (ADPR).
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SARM1 inhibitor NB-3 is a small molecule inhibitor of the nicotinamide adenine dinucleotide (NAD) hydrolase SARM1, targets the NAD-dependent active-site by intercepting NAD hydrolysis and undergoing covalent conjugation with the reaction product adenosine diphosphate ribose (ADPR).
SARM1 inhibitor NB-3 is highly potent and confer compelling neuroprotection in preclinical models of neurological injury and disease.
| M.Wt | 261.248 | |
| Formula | C11H14F3N3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Matthew Bratkowski, et al. Neuron. 2022 Sep 7;S0896-6273(22)00749-8.
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