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Chemical Structure : SARS-CoV-2 nsp14 inhibitor 25
Catalog No.: PC-38498Not For Human Use, Lab Use Only.
SARS-CoV-2 nsp14 inhibitor 25 is a highly potent, selective, nucleoside-derived inhibitor of SARS-CoV-2 nsp14 (N7-guanine)-methyltransferase (N7-MTase) with IC50 of 19 nM, no inhibition against human RNA N7-MTase (hRNMT, IC50>50 uM).
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SARS-CoV-2 nsp14 inhibitor 25 is a highly potent, selective, nucleoside-derived inhibitor of SARS-CoV-2 nsp14 (N7-guanine)-methyltransferase (N7-MTase) with IC50 of 19 nM, no inhibition against human RNA N7-MTase (hRNMT, IC50>50 uM).
SARS-CoV-2 nsp14 N7-MTase catalyzes the transfer of the methyl group from the S-adenosyl-l-methionine (SAM) cofactor to the N7-guanosine cap, which is essential for the stability of viral RNA, translation of mRNAs, and virus evasion from innate immunity.
| M.Wt | 489.507 | |
| Formula | C20H23N7O6S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Rostom Ahmed-Belkacem, et al. J Med Chem. 2022.
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