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SARS-CoV-2 nsp14 inhibitor 25

Chemical Structure : SARS-CoV-2 nsp14 inhibitor 25

CAS No.: 2766190-68-3

SARS-CoV-2 nsp14 inhibitor 25

Catalog No.: PC-38498Not For Human Use, Lab Use Only.

SARS-CoV-2 nsp14 inhibitor 25 is a highly potent, selective, nucleoside-derived inhibitor of SARS-CoV-2 nsp14 (N7-guanine)-methyltransferase (N7-MTase) with IC50 of 19 nM, no inhibition against human RNA N7-MTase (hRNMT, IC50>50 uM).

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    Biological Activity

    SARS-CoV-2 nsp14 inhibitor 25 is a highly potent, selective, nucleoside-derived inhibitor of SARS-CoV-2 nsp14 (N7-guanine)-methyltransferase (N7-MTase) with IC50 of 19 nM, no inhibition against human RNA N7-MTase (hRNMT, IC50>50 uM).
    SARS-CoV-2 nsp14 N7-MTase catalyzes the transfer of the methyl group from the S-adenosyl-l-methionine (SAM) cofactor to the N7-guanosine cap, which is essential for the stability of viral RNA, translation of mRNAs, and virus evasion from innate immunity.

    Physicochemical Properties

    M.Wt 489.507
    Formula C20H23N7O6S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    N-(((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)-3-cyano-N-ethyl-4-methoxybenzenesulfonamide

    References

    1. Rostom Ahmed-Belkacem, et al. J Med Chem. 2022.

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