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SB-258585

Chemical Structure : SB-258585

CAS No.: 209480-63-7

SB-258585 (SB258585)

Catalog No.: PC-63485Not For Human Use, Lab Use Only.

SB-258585 is a potent, selective and orally active 5-HT6 receptor antagonist with Ki of 8.9 nM, >160-fold selectivity over other 5-HT receptor subtypes.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

SB-258585 is a potent, selective and orally active 5-HT6 receptor antagonist with Ki of 8.9 nM, >160-fold selectivity over other 5-HT receptor subtypes.
SB-258585 also is an inhibitor of HCV entry in liver-derived cell lines as well as primary hepatocytes.
SB-258585 modulates localization of the coreceptor tight junction protein claudin-1 (CLDN1) in a 5-HT6-independent manner, induces intracellular accumulation of CLDN1.

Physicochemical Properties

M.Wt 487.356
Formula C18H22IN3O3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-Iodo-N-[4-methoxy-3-(4-methyl-1-piperazinyl)phenyl]benzenesulfonamide

References

1. Hirst WD, et al. Br J Pharmacol. 2000 Aug;130(7):1597-605.

2. Riva L, et al. J Virol. 2018 Apr 27;92(10). pii: e01982-17.

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