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Chemical Structure : SB 224289 hydrochloride
CAS No.: 180084-26-8
Catalog No.: PC-38596Not For Human Use, Lab Use Only.
SB 224289 hydrochloride is a potent, selective 5-HT1B inverse agonist/antagonist with pKi value of 8.16, displays >75-fold selectivity over all other 5-HT receptors.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $158 | In stock | |
| 50 mg | $248 | In stock | |
| 100 mg | Get quote |
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SB 224289 hydrochloride is a potent, selective 5-HT1B inverse agonist/antagonist with pKi value of 8.16, displays >75-fold selectivity over all other 5-HT receptors.
SB 224289 is a potent antagonist of terminal 5-HT autoreceptor function both in vitro and in vivo.
| M.Wt | 557.091 | |
| Formula | C32H33ClN4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Methanone, [2′-methyl-4′-(5-methyl-1,2,4-oxadiazol-3-yl)[1,1′-biphenyl]-4-yl](2,5,6,7-tetrahydro-1′-methylspiro[3H-furo[2,3-f]indole-3,4′-piperidin]-5-yl)-, hydrochloride (1:1) |
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1. Gaster LM, et al. J Med Chem. 1998 Apr 9;41(8):1218-35.
2. Pauwels PJ, et al. Br J Pharmacol. 1998 Jan;123(1):51-62.
3. Verheggen R, et al. Br J Pharmacol. 1998 Aug;124(7):1345-54.
4. J V Selkirk, et al. Br J Pharmacol. 1998 Sep;125(1):202-8.
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