Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : SBI-0498
Catalog No.: PC-20686Not For Human Use, Lab Use Only.
SBI-0498 (SBI-0730498) is a small molecule inhibitor of coronaviruses translation initiation complex 4F (eIF4F), disrupts eIF4F complex formation and inhibits coronavirus RNA and protein levels.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
SBI-0498 (SBI-0730498) is a small molecule inhibitor of coronaviruses translation initiation complex 4F (eIF4F), disrupts eIF4F complex formation and inhibits coronavirus RNA and protein levels.
SBI-0498 inhibits human coronavirus OC43 (HCoV-OC43; OC43) with minimal cell toxicity.
SBI-0498 (0-10 uM) is more potent than remdesivir (Cat# PC-60313) in decreasing the proportion of infected cells when assessed 48 h post treatment, significantly reduces viral RNA levels.
SBI-0498 can dissociate mRNAs from the eIF4F complex.
SBI-0498 reverses gene expression signatures induced upon HCoV-OC43 infection.
| M.Wt | 355.86 | |
| Formula | C21H22ClNO2 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Yongmei Feng, et al.Front Pharmacol. 2022 Dec 1;13:1029093.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
