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Chemical Structure : SBI-425
CAS No.: 1451272-71-1
Catalog No.: PC-62544Not For Human Use, Lab Use Only.
SBI-425 (SBI425) is a potent, selective, orally bioavailable tissue-nonspecific alkaline phosphatase (TNAP) inhibitor with IC50 of 16 nM, shows high selectivity over other alkaline phosphatases including IAP and PLAP.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $138 | In stock | |
| 10 mg | $218 | In stock | |
| 25 mg | $368 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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SBI-425 (SBI425) is a potent, selective, orally bioavailable tissue-nonspecific alkaline phosphatase (TNAP) inhibitor with IC50 of 16 nM.
SBI-425 shows high selectivity over other alkaline phosphatases including IAP and PLAP.
SBI-425 demonstrates activity in blocking calcification in patient derived fibroblasts as well as in rodent models of GACI and PXE.
SBI-425 reduces coronary calcium and lipids, improves body weight and ejection fraction in WHC-eTNAP mice.
| M.Wt | 341.766 | |
| Formula | C13H12ClN3O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
5-((5-chloro-2-methoxyphenyl)sulfonamido)nicotinamide |
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1. Pinkerton AB, et al. Bioorg Med Chem Lett. 2018 Jan 1;28(1):31-34.
2. Romanelli F, et al. PLoS One. 2017 Oct 12;12(10):e0186426.
3. Sheen CR, et al. J Bone Miner Res. 2015 May;30(5):824-36.
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