Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : SBI-581
Catalog No.: PC-72447Not For Human Use, Lab Use Only.
SBI-581 (SBI 581) is a potent, selective inhibitor of serine-threonine kinase TAO3 with IC50 of 42 nM, an STE20-like kinase of the GCK subfamily.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
SBI-581 (SBI 581) is a potent, selective inhibitor of serine-threonine kinase TAO3 with IC50 of 42 nM, an STE20-like kinase of the GCK subfamily.
SBI-581 showed moderate selectivity against a broad panel of kinases (MEKK3 IC50=237 nM), and displayed reasonable PK after i.p. injection.
SBI-581 treatment reduces invadopodia function, 3D growth, and extravasation in vitro and in vivo, promoted TKS5α accumulation at RAB11-positive vesicles;.
SBI-581 exerted its effects through preventing TAO3 phosphorylation of dynein subunit protein LIC2 on S202.
| M.Wt | 383.451 | |
| Formula | C24H21N3O2 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
|
|
1. Shinji Iizuka, et al. Cancer Res. 2021 Mar 15;81(6):1472-1485.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
