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Chemical Structure : SBI-5844
Catalog No.: PC-20685Not For Human Use, Lab Use Only.
SBI-5844 (SBI-1275844) is a small molecule inhibitor of coronaviruses translation initiation complex 4F (eIF4F), disrupts eIF4F complex formation and inhibits coronavirus RNA and protein levels.
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SBI-5844 (SBI-1275844) is a small molecule inhibitor of coronaviruses translation initiation complex 4F (eIF4F), disrupts eIF4F complex formation and inhibits coronavirus RNA and protein levels.
SBI-5844 inhibits human coronavirus OC43 (HCoV-OC43; OC43) with minimal cell toxicity.
SBI-5844 (0-10 uM) is more potent than remdesivir (Cat# PC-60313) in decreasing the proportion of infected cells when assessed 48 h post treatment, significantly reduces viral RNA levels.
SBI-5844 can dissociate mRNAs from the eIF4F complex.
PC-60313 reverses gene expression signatures induced upon HCoV-OC43 infection.
| M.Wt | 335.45 | |
| Formula | C22H25NO2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Yongmei Feng, et al.Front Pharmacol. 2022 Dec 1;13:1029093.
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