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Chemical Structure : SBI-797812
CAS No.: 2237268-08-3
Catalog No.: PC-73039Not For Human Use, Lab Use Only.
SBI-797812 (SBI 797812) is a specific small molecule NAMPT activator with EC50 of 0.37 uM, increases NAMPT-catalyzed NMN synthesis by 2.1-fold (Emax).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $198 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | $488 | In stock | |
| 100 mg | Get quote |
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SBI-797812 (SBI 797812) is a specific small molecule NAMPT activator with EC50 of 0.37 uM, increases NAMPT-catalyzed NMN synthesis by 2.1-fold (Emax).
SBI-797812caused concentration-dependent activation of human NAMPT-mediated NMN production in the presence of NAM, PRPP and ATP, activating NAMPT via SBI-797812 was abolished by NAMPT inhibitors including GNI-50, FK-866, and CHS-828.
SBI-797812 also binds to the NAMPT active site, The Km values of NAMPT for ATP without and with SBI-797812 were 1.73 ± 0.32 and 0.29 ± 0.03 mM, respectively.
SBI-797812 impacted PP consumption and pHisNAMPT reactivity.
SBI-797812 dose-dependently elevated of intracellular NMN and NAD+ levels in A549 cells with 1.5, 1.7, and 2.2-fold in the presence of 0.4, 2, and 10 uM SBI-797812.
SBI-797812 promoted PARP-1 activity in the cellular lysate.
SBI-797812 (20 mg kg−1 i.p.) caused a significant 1.3-fold increase of NAD+ was detected in liver and cardiac tissue in treated mice.
| M.Wt | 402.469 | |
| Formula | C19H22N4O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1-(4-(((1R,5S)-8-Oxa-3-azabicyclo[3.2.1]octan-3-yl)sulfonyl)phenyl)-3-(pyridin-4-ylmethyl)urea |
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1. Gardell SJ, et al. Nat Commun. 2019 Jul 19;10(1):3241.
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