Chemical Structure : SBP-1750
CAS No.:
1884219-70-8
SBP-1750
(SBP1750)
Catalog No.: PC-25796Not For Human Use, Lab Use Only.
SBP-1750 is a novel potent ULK inhibitor with IC50 of 8 nM and 50 nM for ULK1 and ULK2 respectively in ADP-Glo kinase assays, induces effective ATG13 degradation in A549 cells with EC50 of 114 nM in In-Cell Western blots (ICWBs) assays.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
SBP-1750 is a novel potent ULK inhibitor with IC50 of 8 nM and 50 nM for ULK1 and ULK2 respectively in ADP-Glo kinase assays, induces effective ATG13 degradation in A549 cells with EC50 of 114 nM in In-Cell Western blots (ICWBs) assays.
SBP-1750 exhibits cellular activity in the ULK1 NanoBRET assay with IC50 of 4.1 nM.
SBP-1750 may induce ATG13 degradation through a proteasomal pathway, MG132 significantly alters the level of ATG13 degradation.
SBP-1750 impaired ATG, and induced KRAS mutant cancer cell death.
SBP-1750 significantly reduced tumor growth in KRAS-mutant orthotopic syngeneic pancreatic cancer model.
Physicochemical Properties
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M.Wt
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443.89
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Formula
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C21H22ClN5O4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2-((5-chloro-2-((3,4,5-trimethoxyphenyl)amino)pyrimidin-4-yl)amino)-N-methylbenzamide
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References
1. Hagan PM, et al. bioRxiv [Preprint]. 2025 Oct 15:2025.10.14.682402.
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