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Chemical Structure : SBP-3264
Catalog No.: PC-72700Not For Human Use, Lab Use Only.
SBP-3264 (SBP3264) is a sepecific inhibitor of Hippo signaling pathway kinases STK3 and STK4 with low nanomolar potency.
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SBP-3264 (SBP3264) is a sepecific inhibitor of Hippo signaling pathway kinases STK3 and STK4 with low nanomolar potency.
SBP-3264 specifically inhibited the Hippo signaling pathway in cultured mammalian cells and possessed favorable pharmacokinetic and pharmacodynamic properties in mice.
SBP-3264 suppress the proliferation of AML cells in vitro.
SBP-3264 is a valuable chemical probe for understanding the roles of STK3 and STK4 in AML.
| M.Wt | 369.853 | |
| Formula | C19H20ClN5O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Nicole Bata, et al. J Med Chem. 2022 Jan 27;65(2):1352-1369.
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