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2061980-01-4 A potent, selective, and ATP-competitive inhibitor of the mammalian Hippo orthologs, Sterile 20–like kinases MST1 and MST2 with IC50 of 71.1 nM and 38.1 nM, respectively; has a selectivity score of 0.05 against a panel of 468 diverse kinases; inhibits phosphorylation of MOB1 in a dose-dependent manner, activates the downstream effector Yes-associated protein (YAP) and promotes cell growth; attenuates acetaminophen-induced liver injury, promotes liver repair and regeneration in mice; a valuable chemical probe to study the Hippo signaling pathway

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