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Chemical Structure : SC-236
Catalog No.: PC-61664Not For Human Use, Lab Use Only.
SC-236 (SC58236) is a potent, selective, orally active inhibitor of COX-2 with IC50 of 10 nM.
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SC-236 (SC58236) is a potent, selective, orally active inhibitor of COX-2 with IC50 of 10 nM; displays >1,700-fold selectivity over COX-1 (IC50=17.8 uM); exhibits anti-inflammatory properties and potent antimetastatic activity both in vitro and in vivo.
| M.Wt | 401.8 | |
| Formula | C16H11ClF3N3O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Penning TD, et al. J Med Chem. 1997 Apr 25;40(9):1347-65.
2. Lee A, et al. Cancer Res. 2006 Apr 15;66(8):4378-84.
3. Roche-Nagle G, et al. Br J Cancer. 2004 Jul 19;91(2):359-65.
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