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Chemical Structure : SC-58125
Catalog No.: PC-20235Not For Human Use, Lab Use Only.
SC-58125 is a potent, selective inhibitor of COX-2 with IC50 of 0.05 uM, without inhibition on COX-1 (IC50>10 uM).
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SC-58125 is a potent, selective inhibitor of COX-2 with IC50 of 0.05 uM, without inhibition on COX-1 (IC50>10 uM).
SC-58125 inhibited edema at the inflammatory site and was analgesic but had no effect on PG production in the stomach and did not cause gastric toxicity.
SC-58125 suppressed the inflammatory reaction and caused a marked decrease in the level of PGE2 but not TXB2 and 6-keto-PGF 1 alpha.
SC-58125 rapidly reversed paw edema and reduced the level of PGE2 in paw tissue to baseline, also reduced the expression of COX-2 mRNA and protein in the paw.
| M.Wt | 384.35 | |
| Formula | C17H12F4N2O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Seibert K, et al. Proc Natl Acad Sci U S A. 1994 Dec 6;91(25):12013-7.
2. Harada Y, et al. Prostaglandins. 1996 Jan;51(1):19-33.
3. Anderson GD, et al. J Clin Invest. 1996 Jun 1;97(11):2672-9.
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