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Chemical Structure : SC-919
Catalog No.: PC-72584Not For Human Use, Lab Use Only.
SC-919 (SC919) is a potent, selective inhibitor of IP6K (Inositol hexakisphosphate kinase) with IC50 of <5.2, <3.8 and 0.65 nM for human IP6K1/2/3, respectively.
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SC-919 (SC919) is a potent, selective inhibitor of IP6K (Inositol hexakisphosphate kinase) with IC50 of <5.2, <3.8 and 0.65 nM for human IP6K1/2/3, respectively.
SC-919 reduces the export of phosphate in 293 cells via an XPR1-dependent mechanism involving the SPX domain, reduces intracellular InsP7 levels.
SC-919 decreases plasma phosphate levels in rats and monkeys and does not inhibit phosphate intake by the gut or phosphate reuptake by the kidney in rats.
SC-919 decreases the plasma phosphate levels in rats with hyperphosphataemia.
SC-919 increases the intracellular levels of ATP in an XPR1-dependent manner.
SC-919 alleviates CKD-induced hyperphosphataemia and related parameters in adenine-treated rats.
| M.Wt | 407.247 | |
| Formula | C19H16Cl2N2O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Yusuke Moritoh, et al. Nat Commun. 2021 Aug 11;12(1):4847.
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