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Chemical Structure : SCP1 inhibitor GR-28
Catalog No.: PC-22168Not For Human Use, Lab Use Only.
SCP1 inhibitor GR-28 is a covalent small molecule inhibitor of small C-terminal domain phosphatase 1 (SCP1) with kinact/KI 1383 min-1 M-1, causes degrades REST protein in REST-dependent glioblastoma cells.
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SCP1 inhibitor GR-28 is a covalent small molecule inhibitor of small C-terminal domain phosphatase 1 (SCP1) with kinact/KI 1383 min-1 M-1, causes degrades REST protein in REST-dependent glioblastoma cells.
GR-28 inhibits SCP1 capacity to dephosphorylate REST leading to accumulation of phospho-REST and its subsequent proteasomal degradation in vitro.
SCP1 inhibitor GR-28 covalently targets SCP1 Cys 181, and SCP1 C181A mutant shows resistance to GR-28 inhibition.
SCP1 inhibitor GR-28 (4 uM) reduces the transcriptional activity of REST and GR-28 (10 uM) is cytotoxic against high-REST GBM cells.
SCP1 inhibitor GR-28 exhibits profound synergy with ACSL inhibitor Triacsin C in high-REST GBM cells.
| M.Wt | 476.55 | |
| Formula | C26H24N2O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Svetlana B Panina, et al. BMC Biol. 2024 Apr 12;22(1):83.
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