SDUY127 | SHP2 inhibitor | Probechem Biochemicals

Chemical Structure : SDUY127

SDUY127 (SDUY-127)

Catalog No.: PC-26846Not For Human Use, Lab Use Only.

SDUY127 is a potent, bivalent, allosteric inhibitor of SHP2 (PTPN11) with IC50 of 16 nM, exhibits antiproliferative efficacy against MV4-11 cells through suppression of MAPK signaling.

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Biological Activity

SDUY127 is a potent, bivalent, allosteric inhibitor of SHP2 (PTPN11) with IC50 of 16 nM, exhibits antiproliferative efficacy against MV4-11 cells through suppression of MAPK signaling.

Physicochemical Properties

M.Wt	1195.23
Formula	C58H69Cl2N13O9S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N1-(3-((3-amino-5-(4-amino-4-methylpiperidin-1-yl)pyrazin-2-yl)thio)-2-chlorophenyl)-N3-(4-(4-(2-(2-(2-(2-(3-(4-(2-chlorobenzyl)-5-oxo-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinazolin-1-yl)-2-methoxyphenoxy)ethoxy)ethoxy)ethoxy)ethyl)piperazin-1-yl)-4-oxobutyl)malonamide

References

1. Chengchun Zhu, et al. J Med Chem. 2026 May 14. doi: 10.1021/acs.jmedchem.5c03184.

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SDUY127 (SDUY-127)

Biological Activity

Physicochemical Properties

References

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