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Chemical Structure : SEC inhibitor KL-2
CAS No.: 900308-51-2
Catalog No.: PC-35725Not For Human Use, Lab Use Only.
SEC inhibitor KL-2 is a peptidomimetic inhibitor of super elongation complex (SEC) and transcription elongation by Pol II, disrupts cyclin T1-AFF4 interaction (Ki=1.50 uM) within SEC.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $198 | In stock | |
| 10 mg | $298 | In stock | |
| 25 mg | $458 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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SEC inhibitor KL-2 is a peptidomimetic inhibitor of super elongation complex (SEC) and transcription elongation by Pol II, disrupts cyclin T1-AFF4 interaction (Ki=1.50 uM) within SEC.
SEC inhibitor KL-2 disrupts the interaction between the SEC scaffolding protein AFF4 and P-TEFb, resulting in impaired release of Pol II from promoter-proximal pause sites and a reduced average rate of processive transcription elongation.
SEC inhibitor KL-2 attenuates the heat-shock response from Drosophila to human, reduces protein levels of SEC components AFF1 and AFF4, but not CDK9 or CCNT1 in HEK293T cells.
SEC inhibitor KL-2 downregulates MYC and MYC-dependent transcriptional programs in mammalian cells and delays tumor progression in mouse xenograft models of MYC-driven cancer.
| M.Wt | 333.743 | |
| Formula | C17H13ClFNO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-(5-chloro-2-methylphenyl)-4-(4-fluorophenyl)-2,4-dioxobutanamide |
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1. Liang K, et al. Cell. 2018 Oct 18;175(3):766-779.e17.
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