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Chemical Structure : SH-BC-893
CAS No.: 1841409-92-4
Catalog No.: PC-35653Not For Human Use, Lab Use Only.
SH-BC-893 is a water-soluble, orally bioavailable synthetic sphingolipid that triggers nutrient transporter internalization and also blocks lysosome-dependent nutrient generation pathways in cancer cells, activates protein phosphatase 2A (PP2A), leading to mislocalization of the lipid kinase PIKfyve.
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SH-BC-893 is a water-soluble, orally bioavailable synthetic sphingolipid that triggers nutrient transporter internalization and also blocks lysosome-dependent nutrient generation pathways in cancer cells, activates protein phosphatase 2A (PP2A), leading to mislocalization of the lipid kinase PIKfyve.
SH-BC-893 selectively kills cells expressing an activated form of the anabolic oncogene Ras in vitro and in vivo.
| M.Wt | 325.921 | |
| Formula | C19H32ClNO | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
((2S,3R)-3-(4-octylphenyl)pyrrolidin-2-yl)methanol hydrochloride |
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1. Kim SM, et al. J Clin Invest. 2016 Nov 1;126(11):4088-4102.
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