SHP1 agonist SCA9

Chemical Structure : SHP1 agonist SCA9

Catalog No.: PC-26115Not For Human Use, Lab Use Only.

SHP1 agonist SCA9 is a highly selective covalent agonist of SHP1 (SHP-1) targeting Cys102, binds the N-SH2 domain to relieve autoinhibition and activate SHP1 with EC50 of 13.4 uM.

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Biological Activity

SHP1 agonist SCA9 is a highly selective covalent agonist of SHP1 (SHP-1) targeting Cys102, binds the N-SH2 domain to relieve autoinhibition and activate SHP1 with EC50 of 13.4 uM.

Physicochemical Properties

M.Wt	314.73
Formula	C14H11ClN6O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-((5-chloropyrazolo[1,5-a]pyrimidin-7-yl)amino)pyridin-4-yl)acrylamide

References

1. Mei Ying Ng, et al. bioRxiv [Preprint]. 2026 Feb 22:2026.02.19.706790.

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