SHP1 inhibitor M029

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Chemical Structure : SHP1 inhibitor M029

Catalog No.: PC-26204Not For Human Use, Lab Use Only.

SHP1 inhibitor M029 is a covalent, allosteric SHP1 inhibitor with IC50 of 2.6 uM, covalently targets cryptic Cys480 far away from the active site.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

SHP1 inhibitor M029 is a covalent, allosteric SHP1 inhibitor with IC50 of 2.6 uM, covalently targets cryptic Cys480 far away from the active site.
M029 displays >22.4‐fold selectivity over a large panel of mammalian PTPs, including its closely related homolog SHP2.
M029 shows strong efficacy in immune activation, enhanced TCR‐LCK signaling and T cell activation.
M029 inhibits syngeneic MC38 tumor growth by promoting infiltration and activation of both T cells and NK cells in the tumor microenvironment.

Physicochemical Properties

M.Wt	355.81
Formula	C13H10ClN3O3S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-chloro-N-(4-(N-(3-cyanothiophen-2-yl)sulfamoyl)phenyl)acetamide

References

1. Zihan Qu, et al. Angew Chem Int Ed Engl. 2026 Feb 9;65(7):e25126.

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