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SHP2 inhibitor 9

Chemical Structure : SHP2 inhibitor 9

CAS No.: 2055758-04-6

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SHP2 inhibitor 9

Catalog No.: PC-36040Not For Human Use, Lab Use Only.

SHP2 inhibitor 9 is a potent, selective inhibitor of SHP2 with IC50 of 48 nM, inhibits p-ERK in KYSE520 cells with IC50 of 28 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    SHP2 inhibitor 9 is a potent, selective inhibitor of SHP2 with IC50 of 48 nM, inhibits p-ERK in KYSE520 cells with IC50 of 28 nM.
    SHP2 inhibitor 9 demonstrates antiproliferation activity in the EGFR amplified human esophageal squamous cell carcinoma cell line KYSE520 (IC50=220 nM), inhibits p-ERK and DUSP6.

    Physicochemical Properties

    M.Wt 450.99
    Formula C20H27ClN6O2S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    6-amino-2-((3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)-5-((3-chloro-2-methylpyridin-4-yl)thio)-3-methylpyrimidin-4(3H)-one

    References

    1. Sarver P, et al. J Med Chem. 2019 Jan 28. doi: 10.1021/acs.jmedchem.8b01726.

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