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Chemical Structure : SHP394
Catalog No.: PC-36038Not For Human Use, Lab Use Only.
SHP394 (SHP-394, SHP 394) is a potent, selective, orally bioavailable inhibitor of SHP2 with IC50 of 23 nM, shows p-ERK inhibition with IC50 of 18 nM in cellular assays.
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SHP394 (SHP-394, SHP 394) is a potent, selective, orally bioavailable inhibitor of SHP2 with IC50 of 23 nM, shows p-ERK inhibition with IC50 of 18 nM in cellular assays.
SHP394 demonstrates antiproliferation activity in the EGFR amplified human esophageal squamous cell carcinoma cell line KYSE520 (IC50=297 nM), also inhibits Detroit-562 pharyngeal carcinoma cell line in vitro with IC50 of 1.38 uM.
SHP394 shows high lipophilic efficiency, improved potency and enhanced pharmacokinetic properties.
SHP394 exhibits efficacy in pharyngeal carcinoma Detroit-562 xenograft model.
| M.Wt | 470.515 | |
| Formula | C20H25F3N6O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Sarver P, et al. J Med Chem. 2019 Jan 28. doi: 10.1021/acs.jmedchem.8b01726.
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