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Chemical Structure : SHP836
Catalog No.: PC-62631Not For Human Use, Lab Use Only.
SHP836 is a distinct, allosteric site 2 SHP2 inhibitor with IC50 of 12 uM (SHP2 1-525), and selective over the phosphatase domain (SHP2 PTP IC50>100 uM).downregulates DUSP6 mRNA, a downstream MAPK pathway marker, in KYSE-520 cancer cells.
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SHP836 is a distinct, allosteric site 2 SHP2 inhibitor with IC50 of 12 uM (SHP2 1-525), and selective over the phosphatase domain (SHP2 PTP IC50>100 uM).
SHP836 downregulates DUSP6 mRNA, a downstream MAPK pathway marker, in KYSE-520 cancer cells。
SHP836 enhances pharmacological pathway inhibition in cells combined with SHP099.
| M.Wt | 352.263 | |
| Formula | C16H19Cl2N5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Fodor M, et al. ACS Chem Biol. 2018 Jan 18. doi: 10.1021/acschembio.7b00980.
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