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Chemical Structure : SHR170008
Catalog No.: PC-72270Not For Human Use, Lab Use Only.
SHR170008 is a highly potent, small molecule CD73 inhibitor with IC50 of 0.05 nM against human CD73 soluble enzyme.
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SHR170008 is a highly potent, small molecule CD73 inhibitor with IC50 of 0.05 nM against human CD73 soluble enzyme.
SHR170008 inhibits endogenous membrane-bound CD73 using CD73-expressing human melanoma cell line A375 with IC50 of 0.051 nM, much stronger than AMPCP (CI50=16 nM).
SHR170008 reverses the inhibitory effect of adenosine from AMP in the activation and proliferation of CD8+ T cells as well as Granzyme B+ cells in CD8+ cells.
SHR170008 significantly reverses the suppression of IFNγ production with average EC50=110 ± 51 nM in human PBMC.
SHR170008 exhibited in vivo anti-tumor efficacy and synergistic effects in combination with anti-PD-1 mAb in EMT6 mouse syngeneic breast tumor model.
| M.Wt | 537.894 | |
| Formula | C22H25ClN5O7P | |
| Appearance | Solid | |
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1. Suxing Liu, et al. Onco Targets Ther. 2021 Aug 24;14:4561-4574.
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