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Chemical Structure : SI-2
CAS No.: 380537-35-9
Catalog No.: PC-70313Not For Human Use, Lab Use Only.
SI-2 (EPH-116) is a potent small-molecule inhibitor of steroid receptor coactivator-3 (SRC-3 or AIB1) that can selectively inhibit the intrinsic transcriptional activities of SRC-3, also inhibits SRC-1 and SRC-2.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $198 | In stock | |
| 25 mg | $298 | In stock | |
| 100 mg | $698 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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SI-2 (EPH-116) is a potent small-molecule inhibitor of steroid receptor coactivator-3 (SRC-3 or AIB1) that can selectively inhibit the intrinsic transcriptional activities of SRC-3, also inhibits SRC-1 and SRC-2.
SI-2 (EPH-116) selectively reduces cellular protein levels of SRC-3, but not that of CARM-1, blocks MDA-MB-468 cell growth with an IC50 value of 3.4 nM, but spares normal cells.
SI-2 (EPH-116) significantly inhibit primary tumor growth and reduce SRC-3 protein levels in a breast cancer mouse model.
SI-2 (EPH-116) is a "first-in-class" compound that targets oncogenic coactivator.
| M.Wt | 265.3 | |
| Formula | C15H15N5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(1E)-1-(2-pyridinyl)-ethanone-2-(1-methyl-1H-benzimidazol-2-yl)hydrazone |
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1. Song X, et al. Proc Natl Acad Sci U S A. 2016 May 3;113(18):4970-5.
2. Rohira AD, et al. Cancer Res. 2017 Aug 15;77(16):4293-4304.
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