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Chemical Structure : SI-2 hydrochloride
Catalog No.: PC-70314Not For Human Use, Lab Use Only.
A potent small-molecule inhibitor of steroid receptor coactivator-3 (SRC-3 or AIB1) that can selectively inhibit the intrinsic transcriptional activities of SRC-3, also inhibits SRC-1 and SRC-2.
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A potent small-molecule inhibitor of steroid receptor coactivator-3 (SRC-3 or AIB1) that can selectively inhibit the intrinsic transcriptional activities of SRC-3, also inhibits SRC-1 and SRC-2; selectively reduces cellular protein levels of SRC-3, but not that of CARM-1, blocks MDA-MB-468 cell growth with an IC50 value of 3.4 nM, but spares normal cells; significantly inhibit primary tumor growth and reduce SRC-3 protein levels in a breast cancer mouse model; "first-in-class" compound that targets oncogenic coactivator.
| M.Wt | 301.78 | |
| Formula | C15H15N5.HCl | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Song X, et al. Proc Natl Acad Sci U S A. 2016 May 3;113(18):4970-5.
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