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Chemical Structure : SID7969543
Catalog No.: PC-72819Not For Human Use, Lab Use Only.
SID7969543 is a potent, selective and cell penetrant inhibitor of steroidogenic factor 1 (SF-1/NR5A1) with IC50 of 760 nM, also selectively targets KMT2A-rearranged (KMT2A-r) leukemia cells.
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SID7969543 is a potent, selective and cell penetrant inhibitor of steroidogenic factor 1 (SF-1/NR5A1) with IC50 of 760 nM, also selectively targets KMT2A-rearranged (KMT2A-r) leukemia cells.
SID7969543 limited the viability of 7 out of 11 KMT2A-r leukemia cell lines including 5 out of 7 lines derived from infants, without affecting KMT2A-wt leukemia cells, solid cancer lines, non-malignant cell lines, or peripheral blood mononuclear cells from healthy controls.
SID7969543 decreased KMT2A-r leukemia cell viability by inducing caspase-dependent apoptosis within hours of treatment and demonstrated synergy with established chemotherapeutics used in the treatment of high-risk leukemia.
| M.Wt | 452.46 | |
| Formula | C24H24N2O7 | |
| Appearance | Solid | |
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1. Madoux F, et al. Mol Pharmacol. 2008 Jun;73(6):1776-84.
2. Karsa M, et al. Front Oncol. 2022 Jan 20;11:779859.
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