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SJ-300

Chemical Structure : SJ-300

CAS No.: 1210357-06-4

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SJ-300 (SJ300)

Catalog No.: PC-25671Not For Human Use, Lab Use Only.

SJ-300 is a potent and selective inhibitor of the DKK3-LRP1 interaction, effectively reverses the DKK3 inhibition of Aβ clearance.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

SJ-300 is a potent and selective inhibitor of the DKK3-LRP1 interaction, effectively reverses the DKK3 inhibition of Aβ clearance.
SJ-300 effectively binds to mLRPIV with a Kd of 7.9 uM.
SJ-300 markedly impeds the binding of DKK3 to mLRPIV with IC50 of 3.2 uM, does not disrupt the binding of Aβ to LRP1.
SJ-300 (5 mg/kg, orally administered (intragastrically), 0.5% O-carboxymethylcellulose-Na in saline) effectively alleviates cognitive and pathological deficits in 5×FAD mice, promotes peripheral clearance in AD model mice.

Physicochemical Properties

M.Wt 342.46
Formula C20H27FN4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
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Solubility

10 mM in DMSO
Chemical Name/SMILES

1-cyclopropyl-N-((1-(4-fluorophenyl)-3,5-dimethyl-1H-pyrazol-4-yl)methyl)piperidin-4-amine

References

1. Yang R, et al. Sci Adv. 2025 Nov 7;11(45):eadz2099.

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