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SJ1008030

Chemical Structure : SJ1008030

CAS No.: 2863634-96-0

SJ1008030 (SJ 1008030)

Catalog No.: PC-49144Not For Human Use, Lab Use Only.

SJ1008030 is a potent, specific JAK2-degrading, GSPT1-sparing PROTAC.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

SJ1008030 is a potent, specific JAK2-degrading, GSPT1-sparing PROTAC.

Physicochemical Properties

M.Wt 873.950
Formula C42H43N13O7S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-((4-(1-(3-(cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N-(2-(4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperazin-1-yl)ethyl)benzamide

References

1. Yunchao Chang, et al. Blood. 2021 Dec 9;138(23):2313-2326.

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